Dr. B. Karthiha

Research projects

1. Madunil Anuk Niriella , Viranga Sathsarani Ranathunga , Sanduni Nirasha , Rohan Chaminda Siriwardana , Kuleesha Senarath Kodisinghe , Sujeewa Ravindu Kumarasena, Tharanga Liyanaarchchi , Suchintha Bandara Tillakaratne , Hasitha Wijewantha , Uditha Bandara Dassanayake , Vithiya Rishikesawan , Chamila Kumara Ranawaka , Anuradha Kajendran , Karthiha Balendran , Sanjeewa Aryasingha , Duminda Subasinghe , Nilesh Fernandopulle, Sudual Mananjala Senanayake , Anuradha Supun Dassanayake , Ishan deZoysa, Chintahka Viduranga de Silva, Chamila Subasinghe , Sumedha Udumalagala , Supun Kulathunga , Tilan Aponso , Vadivel Vijitharan , Isuru Upanishad , Nanadana Dinamithra , Arunasalam Pathmeswaran , Hithanadura Janaka de Silva. Sri Lanka Society of Gastroenterology Collaborative Hepatocellular Carcinoma Snapshot Audit (SLSG CARSA): A Nationwide, Cross-Sectional Snapshot Study.Pre prints with LANCET, Posted: 12 Nov 2024

2. Chrishanthi Rajasooriyar, Sreekanthan Gobishangar,  Vikneswaran Namasivayam, Chandu De Silva,  Priyani Amaratunga,  Sundaramoorthy Iyer Thuraisamy Sarma, Vinayagamoorthi Thusyanthan,  Anuradha Kajendran,  Antony Joseph Thanenthiran, Thanuja Murugathas,  Karthiha Balendran,  Jathavani MM Theepan, Rajendra Surenthirakumaran. Prevalence of oesophageal premalignant lesions among patients referred for gastro-oesophageal-duodenoscopy at a tertiary care hospital in northern, sri lanka. Diseases of the Esophagus, Volume 37, Issue Supplement_1, September 2024.

3. Christina Kapizioni,  Rofaida Desoki,  Danielle Lam,  Karthiha Balendran,  Eman Al-Sulais, Sreedhar Subramanian,  Joanna E Rimmer,  Juan De La Revilla Negro,  Holly Pavey, Laetitia Pele,  Johanne Brooks,  Gordon W Moran,  Peter M Irving,  Jimmy K Limdi, Christopher A Lamb,  Miles Parkes,  Tim Raine. Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource. Journal of Crohn’s and Colitis, Volume 18, Issue 6, June 2024.

4. R Desoki, C Kapizioni, D Lam, K Balendran, E Al-Sulais, S Subramanian, L Pele, M Parkes, T Raine. Does combination immunomodulator therapy impact real-world biologic effectiveness in Inflammatory Bowel Diseases? A propensity score analysis in patients treated with anti-TNF and non-anti-TNF biologics in the UK IBD BioResource. Journal of crohns & colitis, Volume 18,2024.

5. Safety, Effectiveness, and Treatment Persistence of Subcutaneous Vedolizumab in IBD: A Multicenter Study from the United Kingdom Samuel Hsiang Lim, MBBS, Beatriz Gros, MD, Esha Sharma, MPharm, Anouk Lehmann, MD, James O Lindsay, PhD, Louise Caulfield, Daniel R Gaya, MD, Jo Taylor, BSc, Jimmy Limdi, MBBS, Jon Kwok, MSc, Elinor Shuttleworth, PhD, Anjan Dhar, MD, Gemma Burdge, MBBS, Christian Selinger, MD, Sara Cococcia, MD, Charles Murray, PhD, Karthiha Balendran, MD, Tim Raine, PhD, Becky George, BSc, Gareth Walker, PhD, Robin Aldridge, MBBCh, Peter Irving, MD, Charlie W Lees, PhD, Mark Samaan, PhD Inflammatory Bowel Diseases, izad166, https://doi.org/10.1093/ibd/izad166 Published: 21 August 2023

6. Experience with the use of single use duodenoscopy for ERCP in a tertiary care center Balendran , M. Abdellah Ahmed , T. Karunakaran , G. Corbett UEGW abstract book 2023

7. First line biologic therapy in IBD: a propensity score analysis of 12,747 patients in the UK IBD bioresource C Kapazioni, D Lam, R Desoki, K Balendran, E Alsulais, R Shawkey, L Pele, M Parkes, T Raine UEGW abstract book 2023

8. Second line biologic therapy in ibd: a propensity score analysis of 3,410 patients in the uk ibd bioresource C Kapazioni, D Lam, R Desoki, K Balendran, E Alsulais, R Shawkey, L Pele, M Parkes, T Raine UEGW abstract book 2023

9. Safety of endoscopic surveillance of the transplanted small intestine: A 15 years experience of a large UK Transplant centre. Dr Eman Al Sulais MD, Dr. , Karthiha Balendran Dr , Charlotte Rutter , Dr , Dunecan Massey Dr , Jeremy Woodward Dr Lisa Sharkey Transplantation ■ July 2023 ■ Volume 107 ■ Number 7S

10. Differential efficacy of biologic agents for Inflammatory Bowel Disease Unclassified and comparison with Ulcerative Colitis: a propensity score analysis of 4054 patients from the UK IBD BioResource C Kapizioni, R Desoki, K Balendran, D Lam, R Shawky, L Pele, M Parkes, T Raine Journal of Crohn’s and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i800

11. Accuracy and safety of Lower GI EUS-guided FNA/FNB: A retrospective single center study Michail Galanopoulos1, Karthiha Balendran1, Sibu Varghese1, Nicholas Carroll2, Edmund Godfrey2 ESGE Conference 2022 abstract book

12. Comparative effectiveness of vedolizumab and ustekinumab in Crohn’s disease patients who failed anti-TNF treatment: interrogating 1019 patients from the UK IBD BioResource R.Desoki ,K.Balendran , C.Kapazioni, M.Parkes , T.Raine Journal of Crohn’s and Colitis, Volume 16, Issue Supplement_1, January 2022, Pages i117–i118, Published: 21 January 2022

13. Vedolizumab Associated quality of Life and inflammatory bowel disease control Upon Entering a subcutaneous switching program (VALUE) – Results from a multi-centre UK study Lim1, B. Gros Alcade2, A. Lehmann3, J. Lindsay3, D. Gaya4, L. Caulfield4, A. Dhar5, Ritchie5, J. Limdi6, J. Taylor6, T. Raine7, K. Balendran7, E. Shuttleworth8, J. Kwok8, Cococcia9, C. Murray9, G. Walker10, R. Aldridge10, B. George10, R. Colbert4, P. Journal of Crohn’s and Colitis, Volume 16, Issue Supplement_1, January 2022, Pages i499–i500, Published: 21 January 2022

14. An analysis of the causes of acute upper gastrointestinal bleeding from tertiary care center in Sri Lanka. Balendran K, Sathiabalan, Jeisunthar T, Kajendran A. Journal of Gastroenterology and Hepatology, August 2021, Wileyonlinelibrary.com/journal/jhg

15. Prevalence of periampullary diverticulum and its association with pancreatobilliary disease in patients who undergo endoscopic retrograde cholangiopancreatogram: a single center experience in Sri Lanka. Karthiha Balendran, Meththananda Nawarathne, Vadivelu Vijitharan, Sharafaath Shariff. BMJ clinical gastroenterology – June 2019 – volume 68, issue suppl 1. 10.1136/gutjnl-2019.

16. Microbiological Analysis of Bile in Cholangitis: An Observational Study at National Hospital of Sri Lanka. Karthiha Balendran, Dhanushi Abeynayake, Sharafaath Shariff, Supun Kulathunga, Uditha Dassanayake, Nilesh Fernandopulle, NM Meththananda Nawarathne, Sajeevan Rasanantham, Geethika Patabendige. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019,PE 0008, Wileyonlinelibrary.com/journal/jhg

17. Epidemiological and clinical characteristics of cholangitis in patients with biliary obstruction who need Endoscopic Retrograde Cholangio Pancreatogram (ERCP) in Sri Lanka. Karthiha Balendran, Dhanushi Abeynayake, Sharafaath Shariff1, Vadivelu Vijitharan, Chinthaka de Silva, Uditha Dassanayake, Nilesh Fernandopulle, Meththananda Nawarathne. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PE 0002,Wileyonlinelibrary.com/journal/jhg

18. Review of indications and complications of Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes: A single center experience at National Hospital of Sri Lanka. Karthiha Balendran, Dhanushi Abeynayake, Sharafaath Shariff, Vadivelu Vijitharan, Chinthaka de Silva, Sumedha Udumalagala, Uditha Dassanayake, Nilesh Fernandopulle, Meththananda Nawarathne. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PP 0709, Wileyonlinelibrary.com/journal/jhg

19. Demography, endoscopic findings and Diagnosis in patients undergoing lower gastrointestinal endoscopy for per-rectal bleeding In a tertiary care center of Sri Lanka. Vadivel Vijitharan, Karthiha Balendran, Dhanushi Abeynayake, Sharafaath Shariff, Nandana Pushpakumara Dinamithra, Uditha Dassanayaka, Nawarathne Methandana Mudiyanselage Nawarathne. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PP 0109, Wileyonlinelibrary.com/journal/jhg

20. Analysis of Bowel Preparation for Colonoscopy- A Single centre experience at The National Hospital of Sri Lanka (NHSL). Sharafaath Shariff, Karthiha Balendran, Danushi Abeynayake, Vijitharan Vadivel, Chinthaka De silva, Ranjith Peiris. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PP 0917, Wileyonlinelibrary.com/journal/jhg

21. Surveillance for Colonic Diverticulosis And Demographic and Endoscopic Characteristics In Patients Undergoing Colonoscopy in a Tertiary Care Centre in Sri Lanka. Dhanushi Abeynayake, Karthiha Balendran, Sharafaath Shariff, Gcv De Silva, Vijitharan Vadivel, Kesavan Thuraisingham, Praneeth de Alwis, Uditha Dasanayake, Ranjith Peiris. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PP 0918, Wileyonlinelibrary.com/journal/jhg

22. Demography and Aetiology of Patients Presenting with Upper Gastrointestinal Bleeding To a Tertiary Care Centre in Sri Lanka. Dhanushi Abeynayake, Karthiha Balendran, Sharafaath Shariff, G c v De Silva, Vijitharan Vadivel, Uditha Dasanayake, Ranjith Peiris. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PE 0172, Wileyonlinelibrary.com/journal/jhg

23. Demographic and Endoscopic Analysis Of Patients with Anaemia due to Occult Gastrointestinal Bleeding. Dhanushi Abeynayake, Karthiha Balendran, Sharafaath Shariff, Gcv De Silva, Vijitharan Vadivel, Kesavan Thuraisingham, Praneeth de Alwis, Uditha Dasanayake, Ranjith Peiris. Journal of Gastroenterology and Hepatology, Volume 34 | Supplement 3 | December 2019, PE 0199, Wileyonlinelibrary.com/journal/jhg

24. Should male doctors in Sri Lanka wear a neck tie to be recognized and respected? Prabath K Abeysundara, Nilanga Nishad, Karthiha Balendran, Manod Pabasara, Poornima K Bandara, Narmada M Perera, Heshani De Silva, Shamila De Silva, Maheswaran Umakanth, Prasantha S Wijesinghe. Research article. The Journal of Infection in Developing Countries · May 2019 13(5):445-448. doi:10.3855/jidc.11211

25. A study on knowledge, attitude and perception towards HIV infection among adolescents following secondary education. PK Abeyasundara, K.Balendran et.al. Journal of Ceylon college of physicians. AB 2018/PP31/ College of Physicians 51st annual academic session.

26. When do people go to work after dengue?: A community based descriptive study. A Nishad, PK Abeyasundara, K.Balendran , et al. Journal of Ceylon college of physicians AB 2018/PP02/ College of Physicians 51st annual academic session.

Guidelines

1. ECCO Guidelines on Inflammatory Bowel Disease and Malignancies 2022 Hannah Gordon,a,b Livia Biancone,c Gionata Fiorino,d,e, Konstantinos H. Katsanos,f Uri Kopylov,gEman Al Sulais,h Jordan E. Axelrad,i, Karthiha Balendran,j Johan Burisch,k,l, Lissy de Ridder,m Lauranne Derikx,n,o Pierre Ellul,p Thomas Greuter,q,r Marietta Iacucci,s,t, Caroline Di Jiang,u Christina Kapizioni,v Konstantinos Karmiris,w Julien Kirchgesner,x, David Laharie, Triana Lobatón z,aa Tamás Molnár,bb, Nurulamin M. Noor,cc, Rohit Rao,dd Simone Saibeni,ee,Michael Scharl,ff Stephan R. Vavricka,ff Tim Rainegg, Journal of Crohn’s and Colitis, Volume 17, Issue 6, June 2023, Pages 827–854, Published:18 December 2022

2. Non-alcoholic fatty liver disease-Clinical practice guideline, 2019 Somasundaram NP, Niriella MA, Antonypillai C, Navarathne NMM, Dilrukshi MDSA, K.Balendran et al. Non-alcoholic fatty liver disease-2019, Clinical practice guideline. Sri Lanka Journal of Diabetes, endocrinology and Metabolism.2019;9(2):68-90

Case report publications

1. K.Balendran, S.Udumalagala, N M M Nawarathne. Pyloric stenosis as a manifestation of isolated gastric crohn’s disease responding to intralesional steroid injection and baloon dilatation: a case report, Journal of medical case reports. https://doi.org/10.1186/s13256-019-2272-8.

2. Prabath K. Abeysundara, Inoshi Atukorala, K. P. C. Dalpatadu, Karthiha Balendran, D. S. A. Dilrukshi, G M O Fernando. Rare presentation of refractory thrombotic thrombocytopenic purpura: Jejunal stricture. International Journal of Hematology-Oncology and stem cell Research (eISSN: 2008-2207 Tehran University of Medical Sciences, Tehran, Iran). 2017, 11(4):293-295.

3. K. Balendran, L. D. S. U. Senarathne, and R. D. Lanerolle. Crescentic glomerular nephritis associated with rheumatoid arthritis: a case report. Journal of medical case reports(J Med Case Rep. 2017; 11: 197) Published online 2017 Jul doi: 10.1186/s13256-017-1346-8

4. Karthiha Balendran, Meththananda Nawarathne. Primary hepatic Leiomyosarcoma- A rare case report. Poster presentation at International digestive Disease Forum 2019- Hong Kong. Abstract No -IDDF2019-CASE-0026.

5. Karthiha Balendran, Sumedha Udumalagala, Methananda Nawarathne. Pyloricstenosis as a manifestation of isolated gastric Crohn’s disease responding to intralesional steroid injection and balloon dilatation. Abstract- Poster presentation at International digestive Disease Forum 2019 Hong Kong. Abstract No-IDDF2019-CASE-0033

6. Karthiha Balendran, Meththananda Nawarathne, Chinthaka De silva, Dhanushi Abeynayake, Sharafaath Shariff, Nandana Pushpakumara Dinamithra, Uditha Dassanayake, Vadivelu Vijitharan. A young female with adenocarcinoma of ampulla of Vater. Poster presentation at International digestive Disease Forum 2019- Hong Kong. Abstract No- IDDF2019-CASE-0034

Research presentations

1. Review of indications and complications of percutaneous gastrostomy (PEG) feeding tubes: a single center experience at National Hospital of Sri Lanka- Oral presentation at APDW 2019, Kolkata, India

2. Microbiological analysis of bile in cholangitis; an observational study at national hospital of Sri Lanka- Oral presentation at APDW 2019, Kolkata, India

3. Microbiological analysis of bile in cholangitis; an observational study at national hospital of Sri Lanka- Oral presentation at annual academic sessions of Ceylon college of Physicians, 2019.

4. Epidemiological and clinical characteristics of cholangitis in patients with biliary obstruction who need endoscopic retrograde cholangio pancreatogram (ERCP) in sri lanka. Poster presentation at APDW 2019, Kolkata, India

5. Prevalence of periampullary diverticulum and its association with pancreatobiliary disease in patients who undergo Endoscopic Retrograde Cholangio Pancreatogram (ERCP): A single center experience in Sri Lanka. Poster presentation at International digestive Disease Forum 2019- Hong Kong

Other presentations

1. Treat to target versus standard of care for patients with Crohn’s disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial – 18/03/2022 at CUH

2. Gastroparesis-CNTH-2020

3. Management of antithrombotics in gastrointestinal bleeding, question of risk vs benefit. Young physician forum organized by Ceylon College of Physician: 2019 May.

4. A patient with Chronic diarrhea and Jaundice- Postgraduate Forum National Hospital of Sri Lanka: 2019 March

5. Resource person at palliative care workshop in gastroenterology at annual academic session Ceylon college of physician : 2018 September

6. Drug induced liver injury- Physicians forum, National Hospitals of Sri Lanka: 2018 July

7. Young patient with recurrent ischemic stroke – Palliative care workshop at neurology unit, National Hospital of Sri Lanka: 2017 January

8. A patient with Crescentic Glomerular nephritis associated with Rheumatoid arthritis – Postgraduate Forum National Hospital of Sri Lanka :2015 July

9. Case of a Pulmonary Hypertension with myeloproliferative disorder- Postgraduate Forum National Hospital of Sri Lanka: 2015 July.

• Inflammatory bowel disease
• Liver disease